Drug Discovery for Ion Channels XIII

Drug Discovery for Ion Channels XIII

Friday, February 1, 2013
8:30 AM
 - 5:00 PM
Pennsylvania Convention Center
Room 103AB

Pre-registration for the Drug Discovery of Ion Channels XIII Satellite Meeting is now closed. On-site registration will be available starting at 8:00 AM on Friday, February 1, 2013 outside of Room 103AB.

Ion channels are an important class of therapeutic drug targets, and mutations in ion channel genes are found to be responsible for an increasing number of diseases.  While conventional electrophysiological techniques permit the most detailed and direct study of ion channel function, they are limited due to the manual nature of the method and their low throughput.  Because of this, ion channels remain an underrepresented target class for drug discovery. The advent of higher throughput automated electrophysiology systems has begun to change the face of ion channel drug discovery. This symposium will review the advances in automated electrophysiology and other emerging technologies and their impact on ion channel drug discovery today. This year’s meeting will highlight presentations from users of automated electrophysiology instrumentation as well as other speakers in the field of ion channel drug discovery.  

Program:   

8:00 AM - 8:30 AM Registration/Introduction

8:30 AM - 9:15 AM Keynote Speaker: Laszlo Kiss, SPS, Bristol-Myers Squibb
Ion Channel Drug Discovery: Past, Present, and Future Perspectives

9:15 AM - 9:45 AM Jonathan W. Theile, Pfizer-Neusentis US
Assessment of Na channel Physiology and Pharmacology with Automated Patch Clamp

9:45 AM - 10:15 AM Ron Knox, Bristol-Myers Squibb 
Identifying Modulators of Sodium Channel Activity using Automated Patch Clamp

10:15 AM - 10:45 AM Break

10:45 AM - 11:15 AM Igor Dzhura, Novartis MA
Assay Development for TRPM5 Channel Modulators 

11:15 AM - 11:45 PM Adrienne Dubin, Scripps Research Institute
Inflammatory Signals Enhance Piezo2-Mediated Mechanosensitive Currents

11:45 AM - 12:15 PM Juha Kammonen, Pfizer 
K2P Assay Development on Electrophysiology Platforms

12:15 PM - 1:30 PM Lunch Break

1:30 PM - 2:15 PM Keynote Speaker: Arthur “Buzz” Brown, Chairman & CSO, ChanRx
TdP or not TdP 

2:15 PM - 2:45 PM John Graef, Axion BioSystems
Validation of an Automated Electrophysiology Platform for the Screening of Nicotinic Agonists and Antagonists

2:45 PM - 3:15 PM Claire Townsend, GlaxoSmithKline
From Biophysics to Screening: Applications of an Automated Patch Clamp System in Drug Discovery

3:15 PM - 3:30 PM Break

3:30 PM - 4:00 PM Maria Garcia, Kanalis Consulting
The Role of Kv2 Channels in Pancreatic Hormone Secretion

4:00 PM - 4:30 PM Mat Brock, Axion Biosystems
A High-Throughput Multi-Electrode Array Platform for Phenotypic Electrophysiological Screening

4:30 PM - 5:00 PM Martin Langecker, Technical University Munich
Ion Channels Made from DNA

5:00 PM - 5:15 PM Closing Remarks, Morten Sunesen, Co-Chair

 

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