Sunday, August 14, 2022
17:00 – 19:30
Registration/Information
18:30 – 19:30
Welcome Reception
Monday, August 15, 2022
8:00 – 17:00
Registration/Information
9:30 PM - 9:45 PM
Opening Remarks
Joanna Slusky, University of Kansas, USA, Meeting Organizer
Session I : Bacterial Membranes, Cell Walls, and Transport
Joanna Slusky, University of Kansas, USA, Chair
9:45 – 10:15
Mathias Winterhalter, Jacobs University, Germany
Quantifying the Uptake of Antibiotics into Gram-Negative Bacteria
10:15 – 10:45
Coffee Break
Session II: Bacterial Membranes, Cell Walls, and Transport (Continued)
Joanna Slusky, University of Kansas, USA, Chair
10:45 – 11:15
Federico Iovino, Karolinska Institute, Sweden
New Therapeutic Strategies to Treat Bacterial Infections of the Brain and Fight Antibiotic-Resistance
11:15 – 11:45
Kaspar Locher, ETH Zürich, Switzerland
Structural Basis of Drug Binding to Multidrug Transporters Revealed by Cryo-Electron Microscopy
11:45 – 12:00
Sergei Sukharev, University of Maryland, USA *
Teasing Half-Bilayers: Physicochemical Properties of LPS Monolayers, Electrostatic Asymmetry of LPS-Phospholipid Bilayers and Implications for Drug/Peptide Permeability
12:00 – 13:00
Lunch
Session III: Efflux and Drug Resistance
Colin Kleanthous, University of Oxford, United Kingdom, Chair
13:00 – 13:30
Klaas Martin Pos, Goethe University Frankfurt, Germany
Structural Insights on Drug Transport and Inhibition of Tripartite Efflux Pumps
13:30 – 14:00
Helen Zgurskaya, University of Oklahoma, USA
The Two-Faced Janus of Multidrug Efflux Substrates and Inhibitors
14:00 – 14:15
Andrea Catte, University of Cagliari, Italy *
Molecular Dynamics Simulations of MexB, MexF and MexY Multidrug Transporters of Pseudomonas Aeruginosa
14:30 – 16:00
Poster Session I and Coffee Break
Session IV: Efflux and Drug Resistance (Continued)
Colin Kleanthous, University of Oxford, United Kingdom, Chair
16:15 – 16:30
Vasileios Petrou, Rutgers New Jersey Medical School, USA *
Structural Basis of Lipid A Modification by the Aminoarabinose Transferase ArnT Linked to Polymyxin Resistance
16:30 – 17:00
Georgios Sotiriou, Karolinska Institute, Sweden
Engineering Responsive Nanomaterials Against Infections
Tuesday, August 16, 2022
8:00 – 13:00
Free Time
12:30 – 17:00
Registration/Information
Session V: Engineering Drug Resistance
Peter Kasson, University of Virginia, USA, Chair
13:00 – 13:30
Anushree Chatterjee, University of Colorado Boulder, USA
Fast, Smart Therapeutic Solutions for Pandemic Response
13:30 – 14:00
Yi Yan Yang, A*STAR, Singapore
Macromolecule Engineering Approach to Overcoming Antimicrobial Resistance
14:00 – 14:15
Fredrik Westerlund, Chalmers University of Technology, Sweden *
High-Resolution Bacterial Typing Using Optical DNA Mapping for Diagnosing Bacterial Infections
14:30 – 16:00
Poster Session II and Coffee Break
Session VI: Engineering Drug Resistance (Continued)
Peter Kasson, University of Virginia, USA, Chair
16:15 – 16:45
Cindy Gunawan, University of Technology, Sydney, Australia - Canceled
The Evolution of Bacterial Adaptation Phenomena to Antimicrobial Nanoparticle
16:45 – 17:00
Priscilla Gomes, Auburn University, USA *
The Role of Protein Mechanostability in Antibiotic Resistance
Wednesday, August 17, 2022
8:00 – 17:00
Registration/Information
Session VII: Bacterial Communities and Resistance
Georgios Sotiriou, Karolinska Institute, Sweden, Chair
9:30 – 10:00
Sada Boyd, University of California, Los Angeles, USA
Evaluating the Interaction Between Copper Resistant and Antibiotic Resistant E. Coli
10:00 – 10:15
Daniel Charlebois, University of Alberta, Canada *
Nongenetic Resistance Enhances Population Survival While Hindering the Evolution of Drug Resistance
10:15 – 10:45
Coffee Break
Session VIII: Bacterial Communities and Resistance (Continued)
Birgitta Henriques-Normark, Karolinska Institute, Sweden, Chair
10:45 – 11:15
Peter Kasson, University of Virginia, USA
Improving Small-Molecule Uptake Using Simulations and Data
11:15 – 11:30
Gideon Mamou, University of Oxford
Coordinated Cell Envelope Biogenesis In Gram-Negative Bacteria
11:45 – 13:00
Lunch
Session IX: Antimicrobial Targets
Helen Zgurskaya, University of Oklahoma, USA, Chair
13:00 – 13:30
Joanna Slusky, University of Kansas, USA
Plugging TolC Antibiotic Efflux
13:30 – 13:45
Gnana Gnanakaran, Los Alamos National Laboratory, USA *
Predicting Permeation of Compounds Across the Outer Membrane of Pseudomonas Aeruginosa
13:45 – 14:15
Birgitta Henriques-Normark, Karolinska Institute, Sweden
Pneumococcal Interactions with the Host as a Target for Therapy
14:30 – 16:00
Poster Session III and Coffee Break
Session X: Antimicrobial Targets (Continued)
Helen Zgurskaya, University of Oklahoma, USA, Chair
16:15 – 16:45
Alejandro Vila, CONICET-Instituto de Biología Molecular y Celular de Rosario, Argentina
The Adaptive Success of New Delhi Metallo-Beta-Lactamase Depends on the In-Cell Kinetic Protein Stability
16:45 – 17:00
Adéla Melcrová, University of Groningen, The Netherlands
Lateral Organization of Bacterial Membranes as Antimicrobial Target
Thursday, August 18, 2022
8:00 – 12:15
Information
Session XI: Membranes, Permeation, and More!
Georgios Sotiriou, Karolinska Institute, Sweden, Chair
9:00 – 9:30
Pierre Santucci, The French National Centre for Scientific Research (CNRS), France
Intracellular Localisation of Mycobacterium Tuberculosis Affects Efficacy of the Antibiotic Pyrazinamide
9:30 – 10:00
Michaela Wenzel, Chalmers University of Technology, Sweden
Fluorescence Live Cell Imaging Approaches to Studying Antibiotic Mechanisms of Action And Resistance
10:00 – 10:15
Georgina Plant, University of Bristol, United Kingdom *
Investigating the Use of Sub-Cellular Fluctuation Imaging with Neisseria Gonorrhoeae
10:15 – 10:45
Coffee Break
Session XII: Membranes, Permeation, and More! (Continued)
Georgios Sotiriou, Karolinska Institute, Sweden, Chair
10:45 – 11:15
Colin Kleanthous, University of Oxford, United Kingdom
Principles of Bacterial Outer Membrane Organization
11:15 – 11:45
James C. Gumbart, Georgia Institute of Technology, USA *
Modeling the Assembly of the AcrAB-TolC Multidrug Efflux Pump
11:45 – 12:00
Nandan Haloi, University of Illinois Urbana-Champaign *
Investigating Molecular Mechanisms of Antibiotic Permeation Through Outer Membrane Porins in High Dimensional Conformational Space
12:00 – 12:15
Closing Remarks and Biophysical Journal Poster Awards
Peter Kasson, University of Virginia, USA
Georgios Sotiriou, Karolinska Institute, Sweden
* Contributed Talks selected from among submitted abstracts