Sunday, June 5, 2022
5:00 PM - 6:00 PM
Registration
6:00 PM - 7:00 PM
Welcome Reception
7:00 PM - 8:00 PM
Dinner
8:00 PM - 8:15 PM
Opening Remarks
Merritt Maduke, Stanford University and Linda Columbus, University of Virginia, Conference Organizers
8:15 PM - 9:15 PM
Keynote Address
Anne Kenworthy, University of Virginia
How to Build, Manipulate, and Destroy Functional Nanodomains
9:15 PM - 9:45 PM
Flash Introduction
Monday, June 6, 2022
7:00 AM - 8:30 AM
Breakfast
Session I: Mechanotransduction in the Membrane
Miriam Goodman, Stanford University, Chair
9:00 AM - 9:30 AM
Miriam Goodman, Stanford University
Deciphering Where and How Touch Happens
9:30 AM - 10:00 AM
Bianxiao Cui, Stanford University
Membrane Curvature Initiated Mechanotransduction in Cells
10:00 AM - 10:30 AM
Kate Poole, University of New South Wales, Sydney, Australia
Multiple Pathways of Mechanoelectrical Transduction in Melanoma Cells
10:30 AM - 11:00 AM
Coffee Break and Group Photo
11:00 AM - 11:30 AM
Medha Pathak, University of California, Irvine
PIEZO1 on the Move
11:30 AM - 11:45 AM
Zheng Shi, Rutgers University *
Membrane Curvature Mediated Subcellular Distribution of PIEZO1
11:45 AM - 12:00 PM
Zhouyang Shen, Memorial Sloan Kettering *
A Synergy Between Mechanosensitive Calcium- and Membrane-Binding Mediates Tension-Sensing by C2-Like Domains
12:00 PM - 1:00 PM
Special-topic hosted Lunch Table
Teaching and Mentoring: inclusive practices (Linda Columbus)
1:00 PM - 2:30 PM
Panel Discussion: Challenges of Diversity and Inclusion in Science and Developing Action-Plans for Overcoming Them
Panelists: Linda Columbus, Karen Fleming, Miriam Goodman, Carlos Villalba-Galea
2:30 PM - 4:00 PM
Free Time
4:00 PM - 6:00 PM
Poster Session I
6:00 PM - 7:00 PM
Dinner
Session II: Membrane Organization
Sergio Grinstein, University of Toronto, Canada, Chair
7:00 PM - 7:30 PM
Sergio Grinstein, University of Toronto, Canada
Integration of Mechanosensory Signals by the Spectrin Cytoskeleton in Endothelial Cells
7:30 PM - 8:00 PM
Susan Daniel, Cornell University
Coronavirus Fusion Peptide Interactions with the Host Membrane Leads to Lipid Ordering and Membrane Fusion
8:00 PM - 8:30 PM
Syma Khalid, University of Oxford, United Kingdom
Progress Towards a Computational Bacteriology Approach to Studying Gram-Negative Bacterial Membranes
8:30 PM - 8:45 PM
Ting-Sung Hsieh, UT Southwestern *
Dynamic Remodeling of Host Membranes by Self-Organizing Bacterial Effectors
8:45 PM - 9:00 PM
Ivan Castello Serrano, University of Virginia *
Rafting in a Rush: Membrane Microdomains in Secretory Trafficking
9:00 PM - 11:00 PM
Mixer
Tuesday, June 7, 2022
7:00 AM - 8:30 AM
Breakfast
Session III: Signaling through the Membrane
William Kobertz, University of Massachusetts Medical School, Chair
9:00 AM - 9:30 AM
William Kobertz, University of Massachusetts Medical School
Fluorescent Visualization of Cellular Fluxes
9:30 AM - 10:00 AM
Anne Carlson, University of Pittsburgh
Phosphate Position is Key in Mediating the TMEM16A-PI(4,5)P2 Interaction
10:00 AM - 10:30 AM
Ming-Feng Tsai, University of Colorado
Mechanisms and Significance of Tissue-Specific Mitochondrial Calcium Uptake
10:30 AM - 10:45 AM
Coffee Break
10:45 AM - 11:15 AM
Patrick Barth, EPFL, Switzerland
Uncovering and Reprogramming Allosteric Signal Transductions in GPCRs
11:15 AM - 11:45 AM
Carlos Villalba-Galea, University of the Pacific
New Insights into the Modal Activity of KV7 Channels
11:45 AM - 12:00 PM
Jorge E. Contreras, University of California, Davis *
Large-Pore Channels as Transporters: Lessons from Connexin, Pannexin and CALHM1 Channels
12:00 PM - 1:00 PM
Special-topic hosted Lunch Table
Careers: Being a Professor at a Teaching University (Carlos Villalba-Galea)
1:00 PM - 2:30 PM
Workshop: Tips for Successful NIH Grant Proposals
Zhongzen Nie, NIH, NIGMS
2:30 PM - 4:00 PM
Free Time
4:00 PM - 6:00 PM
Poster Session II
6:00 PM - 7:00 PM
Dinner
Session IV: Membrane Shape
Dimitrios Stamou, University of Copenhagen, Denmark, Chair
7:00 PM - 7:30 PM
Dimitrios Stamou, University of Copenhagen, Denmark
Membrane Curvature as A Regulator of GPCR Organization at the Plasma Membrane
7:30 PM - 8:00 PM
Alexey Ladokhin, University of Kansas
Lipids and Divalent Cations as Regulators of Bilayer Insertion of pHLIP and Bcl-2 Proteins
8:00 PM - 8:30 PM
Jeet Kalia, Indian Institute of Science Education and Research Bhopal, India
Employing the Double Knot Toxin-TRPV1 Ion Channel Complex as a Model System to Interrogate the Roles of Protein-Membrane Interactions in Protein Function
8:30 PM - 8:45 PM
Tugba N. Ozturk, Washington University *
Elimination of Membrane Deformations Drives CLC-ec1 Dimerization
8:45 PM - 9:00 PM
Giacomo Fiorin , NIH *
Potentials of Mean Force of Biomembrane Deformation
9:00 PM - 11:00 PM
Mixer
Wednesday, June 8, 2022
7:00 AM - 8:30 AM
Breakfast
Session V: Ion Channels and Transporters
Joseph Mindell, NINDS, NIH, Chair
9:00 AM - 9:30 AM
Erkan Karakas, Vanderbilt University
Structural Basis for Activation and Gating of IP3 Receptor Calcium Channels
9:30 AM - 10:00 AM
Joseph Mindell, NINDS, NIH
Fat Chances: How a Signaling Lipid Influences Lysosomal pH Via the Chloride Transporter ClC-7
10:00 AM - 10:30 AM
Emily Liman, University of Southern California
Structure and Function of the OTOP Proton Channels
10:30 AM - 10:45 AM
Coffee Break
10:45 AM - 11:15 AM
Randy Stockbridge, University of Michigan
Structural Determinants of Substrate Specificity in Small Multidrug Resistance Transporters
11:15 AM - 11:30 AM
Olive E. Burata, University of Michigan *
Elucidating the Substrate Specificities of the Two Major Functional Subtypes in the Small Multidrug Resistance (SMR) Family
11:30 AM - 11:45 AM
Huong T. Kratochvil, University of California, San Francisco *
Designed Proton Channels Reveal Mechanisms for Proton Channel Selectivity and Conductivity
11:45 AM - 12:00 PM
Jun Chen, Genentech *
TRPA1 – Biased Agonism and Structural Mechanisms of Modulation
12:00 PM - 1:00 PM
Special-topic hosted Lunch Table
Careers: Research in Biotech (Jun Chen, Genentech)
1:00 PM - 2:30 PM
Panel Discussion: Establishing Expectations and Benchmarks in Collaborations Between Experiment and Computation
Panelists: Linda Columbus, Jessica Swanson, Syma Khalid, and Joseph Mindell
2:30 PM - 4:00 PM
Free Time
4:00 PM - 6:00 PM
Poster Session III
6:00 PM - 6:30 PM
Dinner
6:30 PM - 7:00 PM
Business Meeting
Session VI: Membrane Protein Dynamics
Linda Columbus, University of Virginia, Chair
7:00 PM - 7:30 PM
Linda Columbus, University of Virginia
Impact of Lipid-Membrane Protein Interactions on Membrane Protein Structure and Dynamics
7:30 PM - 8:00 PM
Jessica Swanson, The University of Utah
Kinetic selection of competing ion exchange pathways: When does the electrical versus chemical gradient matter?
8:00 PM - 8:30 PM
Lynmarie Thompson, University of Massachusetts, Amherst
NMR and Hydrogen Exchange Studies of Bacterial Chemotaxis Receptor Complexes Suggest Protein Stabilization is Key to the Signaling Mechanism
8:30 PM - 8:45 PM
Shwetha Srinivasan, Massachusetts Institute of Technology *
Lipid Dependence of the Conformational Coupling Across the Membrane Bilayer of Full-Length Epidermal Growth Factor Receptor
8:45 PM - 9:00 PM
Damien Thévenin, Lehigh University *
Promoting Receptor Protein Tyrosine Phosphatase Activity by Targeting Transmembrane Domain Interactions
9:00 PM - 11:00 PM
Mixer
Thursday, June 9, 2022
7:00 AM - 8:30 AM
Breakfast
Session VII: Membrane Protein Folding
Karen Fleming, Johns Hopkins University, Chair
9:00 AM - 9:30 AM
Karen Fleming, Johns Hopkins University
SurA: a “Groove-y” Chaperone That Expands Unfolded Outer Membrane Proteins
9:30 AM - 10:00 AM
Jonathan Schlebach, Indiana University Bloomington
Coordination of -1 Programmed Ribosomal Frameshifting by the Transcript and Nascent Polypeptide
10:00 AM - 10:30 AM
Ismael Mingarro, University of Valencia, Spain
Deciphering an Interfaciality Scale for Proteins at Biological Membranes
10:30 AM - 10:45 AM
Coffee Break
10:45 AM - 11:15 AM
Joanna Slusky, University of Kansas
Colicin E1 Opens Its Hinge to Plug TolC
11:15 AM - 11:30 AM
Kaitlyn V Ledwitch, Vanderbilt University *
Integrative Structural Modeling of Membrane Proteins Using Sparse Paramagnetic NMR and Neutron Scattering Data
11:30 AM - 11:45 AM
Zuzana Coculova, University of Oxford, United Kingdom *
Droplet-On-Hydrogel Bilayer Based Assay for Functional Study of Membrane Proteins
11:45 AM - 12:00 PM
Shirley Schreier, University of San Paola, Brazil *
Half a Century Deciphering Membrane Structure, Dynamics and Function Based on a Commentary in Biophysical Reviews, 13:849–852 (2021)
12:00 PM - 1:00 PM
Special-topic hosted Lunch Table
Publishing: Thoughts from the Perspective of Academic Editors (Dimitrios Stamous, BJ editor; Joseph Mindell, JGP editor, Merritt Maduke, eLife & BJ editor)
1:00 PM - 4:00 PM
Free Time
4:00 PM - 6:00 PM
Poster Session IV
6:00 PM - 7:00 PM
Dinner
Closing Remarks and Biophysical Journal Poster Awards
Session VIII: Membrane Remodeling, Fusion, and Exocytosis
Kelly Lee, University of Washington
7:00 PM - 7:30 PM
Kelly Lee, University of Washington
Dissecting Membrane Structure and Remodeling Using Cryo-Electron Tomography
7:30 PM - 8:00 PM
Gregory Voth, University of Chicago
Membrane Remodeling by Proteins: Insights and Surprises from Multiscale Computer Simulation
8:00 PM - 8:30 PM
Peter Kasson, University of Virginia
Protein Activation and Membrane Deformation in Enveloped Virus Entry
8:30 PM - 8:45 PM
Volker Kiessling, University of Virginia *
Lipid Protein Interactions Guiding Fusion Pore Opening and Expansion During Regulated Exocytosis
8:45 PM - 9:00 PM
Joana Paulino, University of California San Francisco *
Characterization of the Elusive SERINC5-AP2-Nef Complex in the Context of a Lipid Bilayer
9:00 PM - 11:00 PM
Mixer
Friday, June 10, 2022
7:00 AM - 8:30 AM
Breakfast and Departure
* Short Talks selected from among submitted abstracts