Shape, function, dynamics, and application of supercoiled nanocircle DNA
Event date:
Wednesday, Oct 27, 2021 - Wednesday, Oct 27, 2021 Export event
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This event will be held on October 27 from 9 am - 12 pm CDT
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This event is organized by BPS member E. Lynn Zechiedrich, Baylor College of Medicine.
Click here to Register for this Free Event
Click here to Register for this Free Event
Useful properties emerge in nanometer-sized particles, including improved cell transfection, tissue-specific cell binding, and controlled, site-specific delivery of therapeutics. In this virtual networking event, we will bring together researchers interested in the modeling, design, function, and synthesis of DNA at the nanoscale.
Event Speakers
Moderator: De Witt Sumners (Florida State University, Tallahassee, Florida, USA; https://www.math.fsu.edu/~sumners/)
Alexey Savelyev - University of Montana
Jonathan Fogg - Baylor College of Medicine
Radost Waszkiewicz - University of Warsaw
Maduni Ranasinghe - University of Lethbridge
Alice Pyne - Sheffield University
Björn Högberg - Karolinska Institutet
Wilma Olson - Rutgers University
Event Schedule
Session One:
| 9:00 am |
"Seeing is believing - direct observation of changes in the helical structure of supercoiled DNA" by Alice Pyne, PhD, MRC/UKRI Innovation Fellow and Lecturer in Soft Matter/Polymers, Sheffield University, United Kingdom (https://pyne-lab.uk/) |
| 9:15 am |
"Nanoscale Receptor Clustering with DNA Origami and Measuring Clusters" by Björn Högberg, PhD, Professor, Dept. of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden (http://www.hogberglab.net/) |
| 9:30 am |
“Interplay of DNA Topology and Protein Interactions in Gene Regulation and Organization” by Wilma Olson, PhD, Mary I. Bunting Professor of Chemistry, Rutgers University, Piscataway, New Jersey, USA; (https://chem.rutgers.edu/people/faculty-bio/185-olson-wilma-k) |
| 9:45 am |
Questions for Speakers of Session One |
| 10:00 am |
Discussion/Networking |
| 10:15 am |
Break and Continued Networking |
Session Two:
| 10:30 am |
“Supercoiling and Looping Promote DNA Base Pair Disruption and Coordination Among Distant Sites” by Jonathan Fogg, PhD, Senior Staff Scientist in the Zechiedrich group, Baylor College of Medicine, Houston, Texas, USA (https://www.bcm.edu/research/faculty-labs/lynn-zechiedrich-lab) |
| 10:45 am |
“Assessment of the DNA Partial Specific Volume and Hydration Layer Properties from CHARMM Drude Polarizable and Additive MD Simulations” by Alexey Savelyev, PhD, Research Assistant Professor, University of Montana, working with the Demeler group, University of Lethbridge, Lethbridge, Alberta, Canada; (https://uniweb.uleth.ca/members/1161) |
| 11:00 am |
“Biophysical Characterization of DNA Minicircle Topoisomers to Derive Anisotropy and Partial Specific Volume Using a Global Analysis of Analytical Ultracentrifugation Data” by Maduni Ranasinghe, Graduate Student in the Demeler group; University of Lethbridge, Lethbridge, Alberta, Canada (https://uniweb.uleth.ca/members/1161) |
| 11:15 am |
“Looped DNA: Supercoiling-Dependent Shape and Hydrodynamics” by Radost Waszkiewicz, Graduate Student in the Lisicki and Szymczak group, University of Warsaw, Warsaw, Poland (https://www.fuw.edu.pl/~piotrek/) |
| 11:30 am |
Questions for Speakers of Session Two |
| 11:45 am |
Networking/Discussion of Session Two |
| 12:00 pm |
End of Event |