The Macromolecular Machines & Assemblies Subgroup (formerly Molecular Biophysics Subgroup) is comprised of about 300 members with interests that span all areas of molecular biophysics. In particular these areas include:

• • structures, conformational switching, and deformational dynamics of biological macromolecules and their supramolecular assemblies.
• • thermodynamics and kinetics of the processes that these macromolecules undergo, such as DNA replication, protein synthesis, self-assembly, self-organization, molecular recognition and binding, signaling, catalysis, and metabolic control.
• • responses of biological macromolecular systems to various imposed perturbations, such as (a) changes in temperature, ligand concentration, ionic strength, water activity, solvent polarity, hydrostatic pressure, osmotic pressure of volume-exclusion agents, denaturant concentration, and mutation of the primary sequence, (b) electric, magnetic, electromagnetic and hydrodynamic flow fields, and (c) stretching, bending and torsional strain.
• • diffusive, field-induced, and convective transport of both small and large molecules under various conditions, or through various media or channels of biophysical, biochemical or biological relevance.
• • experimental methods (physical, molecular biological, and chemical) that are used to isolate and characterize biological macromolecules and assess their relevant properties, or to achieve particular assembly or folding targets.
• • theoretical and computational methods used to interpret previous results and future experiments.
  Annually, the Subgroup holds a topical symposium, which is organized by the current Subgroup chair.