The Physical Cell Biology Subgroup (formerly Cell Biophysics Subgroup) aims to bring biophysical studies into cells to probe structures, functions, dynamics, and interactions of macromolecules in their own physiological context. A living cell is a complex entity; the heterogeneous cellular environment is drastically different from the homogenous, well-mixed situation in vitro. Recent technical advances have made it possible to probe the inner working of cells with unprecedented resolution, sensitivity, and specificity; new experimental and computational studies have provided invaluable, quantitative understandings of cellular processes. The Subgroup will provide a much-needed platform for researchers to share scientific ideas, discuss research results, forge new collaborations, and together, to push the frontiers of knowledge in cell biophysics. The Subgroup will also sponsor the Early Career Award and the Student Award in Physical Cell Biology annually, for excellence in the field at these two career stages.