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A variety of biological processes rely on the fine-tuned interaction between the membrane and its microenvironment. Membrane function is modulated as a result of changes in physicochemical properties resulting from intermolecular interactions among proteins and lipids, including the cytoskeleton and glycocalyx. Membrane shape (morphology) is one possible way for the membrane to convey its message. While the basic structure underlying the formation of biological membranes is the lipid bilayer; which is an intrinsically flat, planar structure; cells and organelles also present other morphologies. Physical forces modulate membrane shape, but membrane shape itself is a distinct physical property that can determine biological processes. Membrane shape and shape changes could trigger particular biological responses, depending on the modulation of intricate arrays of interactions between the membrane and its microenvironment.

This event will be held on December 11, from 11:25 am - 1:25 pm, EST.
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This event is organized by Richard Epand and Jose Carlos Bozelli, Junior, both of McMaster University, Hamilton, ON, Canada.

In this virtual conference, Richard Epand from McMaster University will begin by presenting an overview of the conference format as well as a brief opening about Membrane Shape recognition. The first speaker will be Bianxiao Cui from Stanford University, who will talk about using nanofabricated surfaces to induce membrane shape changes and, consequently, triggering the redistribution of proteins in these cells. Next, Matthew Paszek of Cornell University will talk about the modulation of cell shape, particularly by the cellular glycocalyx. He will describe the coupling between membrane shape and the physicochemical structure of the glycocalyx. Following, Patricia Bassereau from the Institute Curie will talk about the two-way road coupling membrane shape and protein distribution/conformation. Complementing the above experimental approaches, Siewert J. Marrink from the University of Groningen will talk about how computer simulation could provide sub-molecular information in the relationship between membrane shape and lipid/protein sorting. To finalize José C. Bozelli Jr will close the conference and suggest areas of future development.    

Event Speakers

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Richard Epand, McMaster University
Matthew Paszek, Cornell University
Bianxiao Cui, Stanford University
Patricia Bassereau, Institute Curie
Siewert J. Marrink, Groningen University
J. Bozelli, McMaster University
 

Event Schedule

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